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5a). 2009-07-28 · Conditional knockout of both Lgr4 and Lgr5 in the gut results in Wnt signaling inhibition and results in the rapid demise of intestinal crypts (PubMed:21727895). Simultaneous knockdown of LGR4, LGR5 and LGR6 results in developmental phenotypes, such as cleft palate and ankyloglossia, but not in tetra-amelia with lung agenesis (PubMed: 29769720 ). 3 Publications Rank scores of expression calls are normalized across genes, conditions and species.

Gene Symbol, LGR5. Protein Length, Partial (see sequence information for more details). Product Type, Recombinant Protein. Cross Reactivity Det här protokollet beskriver beredning av sorterade stem (Lgr5+) och of stem cells in small intestine and colon by marker gene Lgr5. Nature.

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6. Garcia MI, et al. 2009.

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Öga CAMK1D, ADAMTS9, THADA, TSPAN8/LGR5, men det är mer oklart vari denna koppling to a novel type 2 diabetes gene. Diabetologia.

doi: 10.1038/nature22081. 2020-06-10 · Gene expression analysis for Lgr5 across various stages of tumorigenesis in C3-(1) Tag ER − and MMTV-PyMT ER + mouse models showed that C3-(1) Tag mice had upregulated expression of Lgr5 at the hyperplastic stage whereas MMTV-PyMT showed no increase (Fig.
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Aug 31, 2019 Gene: LGR5; leucine rich repeat containing G protein-coupled receptor 5. Aliases : FEX, HG38, GPR49, GPR67, GRP49. Location: 12q21.1. LGR5 (leucine rich repeat containing G protein-coupled receptor 5) · Non- annotated gene. Preliminary data : if you are an author who wish to write a full paper/card May 22, 2014 Lgr5, a member of the G-protein-coupled receptor (GPCR) superfamily, is a known downstream target gene activated by Wnt signaling and a HGNC data for LGR5. Approved symbol. LGR5.

GeneCards ®: The Human Gene Database GeneCards is a searchable, integrative database that provides comprehensive, user-friendly information on all annotated and predicted human genes. The knowledgebase automatically integrates gene-centric data from ~150 web sources, including genomic, transcriptomic, proteomic, genetic, clinical and functional information. A EGFP-IRES-creERT2-WPRE-polyA expression cassette was knocked into the Lgr5 gene start codon site via CRISPR/Cas9 mediated recombination. Gene: LGR5; leucine rich repeat containing G protein-coupled receptor 5: Aliases: FEX, HG38, GPR49, GPR67, GRP49 : Location: 12q21.1: Summary: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. PrimePCR™ PreAmp for SYBR® Green Assay: LGR5, Human Reaction: 400 reactions Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis. The gene LGR5 may have Genomic and Proteomic products available from Sigma-Aldrich. The following LGR5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq).
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Tested in Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Oct 3, 2018 The intestinal epithelium is the most rapidly self‐renewing tissue in adult mammals. We originally defined Lgr5 as a Wnt target gene, May 28, 2020 Organoid growth and Wnt target gene expression were maintained over passages in Lgr5 KOs demonstrating that long‐term replating of Lgr5 KO Jan 31, 2019 cardiac cells (Figure S2). Among the newly identified marker genes, we most notably focused on the Wnt signal activator gene LGR5 because Sep 27, 2017 For genetic lineage tracing, Lgr5-EGFP-IRES-cre/ERT2 mice were crossed To induce the expression of the reporter gene, a single dose of Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) is a seven transmembrane-domain receptor that is a target gene for Wnt and marks stem cells Apr 18, 2017 Lgr5, CSCs-related genes and RSPO2 are overexpressed in ESCC KYSE450 spheroid body cells. A growing body of evidence demonstrates that Jul 27, 2015 The Wnt target gene Lgr5 has been recently identified as a novel stem cell marker of the intestinal epithelium [16,17] and the hair follicle [18,19] Jun 1, 2017 For analysis of the LGR5 gene from FFPE material, the PyroMark CpG Assay Hs_LGR5_02_PM covering three potential CpG sites within the Antigen Information. Accession Number: O75473. Gene ID: 8549. Gene Symbols: LGR5. Protein Name & Synonyms: LGR5/GPR49 (N-term).

MANE Select v0.92, LGR5-203: ENST00000540815.2 Your search resulted in multiple matches.
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enQuireBio™ Recombinant Human LGR5 Protein 100μg...

129 Among this gene signature was the View mouse Lgr5 Chr10:115450314-115587780 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression While the role of nuclear Lgr5 in the gastric epithelium and in cancer cells remains largely unexplored, it is worth noting that several studies examining Lgr5 (+) cells based their identification of Lgr5 (+) cells based on LGR5 mRNA expression and/or LGR5-driven reporters (ex. Lgr5-lacZ), where the sub-cellular localization of reporters may LGR5 plays an important role in the self-renewal of stem cells and is used as a marker identifying self-renewing stem cells in small intestine and hair follicles.